AUTHOR’S ABSTRACT OF THIS PAPER ISSUED 
BY THE BIBLIOGRAPHIC SERVICE, SEPTEMBER 13 
FURTHER CHANGES IN THE WHITE-EYE SERIES OF 
DROSOPHILA AND THEIR BEARING ON THE 
MANNER OF OCCURRENCE OF MUTATION 
H. J. MULLER 
Department of Zoology, University of Texas 
THREE FIGURES 
CONTENTS 
ATA ROMUICELOHES Sey ramet vere ie he cic Se histak Slocastldlate eareick See MEP D re) coe 443 
HGR CRUE 1 SERN EIR ted hoe os ce. sd ucheivat bee eg eae Lk 445 
A. Manner of origin, and time of occurrence of the mutation....... 445 
B. Locus, and mode of reaction with other members of the W series 446 
ETE TENOR Z Se nse ek ee ee Mea Te NG EP 446 
AS Nico nemtion Omigam ! Lins 26 )5 ff. eee ae et cece ale 1a ee eR 446 
B. Its reactions with the W series of allelomorphs.:................ 448 
PPO CUS OLE ROT Sao 5 5 acai eee ee Aa Ne TS Sette 6 fas lei SRE 2A OI 448 
De einerat which the mutation, occurred...) oo... Jai. 3.1. See se 449 
LUE, ANNIE SENSES bt Re Eo ed ee ee ME en 450 
PATA elit ta STE Ud OT RATT coche ok kA opty eek Sed eons acre, wndtous. evant ete ‘ats bees 450 
B. Genetic behavior......... he AERA OCR BI Su Ba kh 4, Se 452 
Dee ae possible additional allelomorphss 612220, 2.0...04 260 .. J.n do eee 452 
V. The mutations of W as quantitative fluctuations of the gene.......... 454 
VI. The stage in the life-cycle at which mutation occurs.................. 459 
VII. The degree of localization of the event which produces the mutation.. 469 
SHUTOANIT ENA Pee INS ee Ps oie Sen Ney ete: D107, WAN sR rg «AA OL OE 470 
Tinea iIbeNenbed Ma tenets fo cote coer arenes alas bee) stl | tPA eee oes 473 
The locus designated as W has yielded: the largest series of 
multiple allelomorphs so far observed in Drosophila. It was at 
this locus that the factor for white eyes (w) was found by Mor- 
gan (’10), whence the designation W for the normal allelomorph; 
subsequently to this eosin (we) was found at the same locus by 
Morgan (712), cherry (w*) and buff (w») by Safir (13, 716), 
blood (w*!) and tinge (wt) by Hyde (’16), and coral (w) by 
Lancefield (18). The case of deficiency (Notch 8) found by 
Mohr (719) should also be listed here, as this included a muta- 
tion in the locus W; although flies homozygous for this mutant 
443 
