GROWTH AFFECTED BY FEEDING DUCTLESS GLANDS 299 



Thymus feeding 



For complete literature see Vincent ('12), Biedl ('13), Basch 

 ('13) and Paton ('13). 



Gudernatsch ('12) ('14) found that a thymus diet stimulated 

 body growth in tadpoles, but retarded metamorphosis of the 

 limbs and tail. Similar results in some cases were obtained 

 by Romeis ('15) and Abderhalden ('15). 



Gebele ('11) and Miss Hewer ('14) reported negative results 

 with thymus feeding. In the latter's work, thymus, when fed 

 (1 to 4 g. daily) to males, retarded the development of the testes 

 in young rats and caused degeneration of the testes in adults. 



Salkind ('15) reported stimulation of growth from feeding 

 large amounts of thymus. 



Hypophysis experiments 



Gushing ('12) concludes that total loss of the anterior lobe 

 of the hypophysis is followed by death and that partial loss is fol- 

 lowed by obesity, sexual infantilism, and retardation of skeletal 

 growth. 



Frequent injections of hypophysis extract interfere with 

 growth, (Cerletti '09, Fodera and Pittau '09). A loss in weight 

 with no skeletal changes is reported by Franchini ('10) and by 

 Crowe, Gushing and Homans ('10). A gain in weight after 

 continued injections of hypophysis extract is reported by Delille 

 ('09), and cardiac hypertrophy by Etienne and Parisot ('08); 

 but Gaselli ('00) obtained negative results. 



Retardation in growth (especially skeletal) as a result of 

 hypophysis feeding was reported by Thompson and Johnston 

 ('05), Etienne and Parisot ('08), Sandri ('07), ('09) (posterior 

 lobe), and Gushing and Goetsch (cited by Gushing ('12), Wulzen 

 ('14) and by Pearl ('16) (anterior lobe) Abderhalden ('15), 

 ana Robertson ('16). 



Negative results from feeding hypophysis are reported by 

 GaselH ('00), Sandri ('09) (anterior lobe), Hoskins ('11), Aldrich 

 ('12a) ('12b), Schafer ('12), Lewis and Miller ('13), and Guder- 

 natsch ('14). 



