300 E. R. HOSKINS 



Schafer ('09) had thought that feeding small amounts of an- 

 terior lobe of the hypophysis favors growth. Goetsch ('16) 

 from very few data reports that excessive dosage retards growth 

 in young rats, whereas smaller dosage accelerates growth in 

 body weight and especially the development of the sexual system ; 

 that this acceleration is due to the anterior lobe; and that feed- 

 ing posterior lobe does not accelerate growth, and even retards 

 sexual development. Robertson ('16a) reports that hypophysis 

 extract accelerates growth after inanition. 



So far as the literature shows, in none of the above experiments 

 with hypophysis substance was a complete autopsy performed 

 or complete histological examination made. Halhon and Alquier 

 ('08) report hypertrophy of the suprarenals in rabbits, and no 

 changes in the gonads. Wulzen ('14) noted in chickens fed 

 fresh hypophysis that the long bones were shorter than in her 

 control animals, and that the involution of the thymus was 

 hastened by the treatment. 



Pineal experiments 



In experiments on growth, Dana and Berkeley ('13) reported 

 that after injecting and feeding a few young animals with pineal 

 substance, they noted growth acceleration. These results may 

 be due to the pineal medication or merely to normal variation. 

 Berkeley ('14) reported mental and physical improvement in 

 backward children to whom pineal substance was administered. 



Priore ('15) reports that young rabbits into which pineal ex- 

 tract was injected frequently, grew slightly more than the con- 

 trols, but his results are probably within normal variability. 

 In an older group the controls outgrew the experimental group. 

 In none could any skeletal alterations be seen. 



McCord ('14) fed pineal substance to a few chicks, young 

 guinea pigs and pups. He reported an acceleration in their 

 rate of growth, increased mentality in the dogs, and sexual 

 precocity in seme of the guinea pigs. 



The same writer ('15) later reported that the growth of young 

 guinea pigs which received daily 10 mgms. of pineal substance 

 from adult cattle was delayed. Adult guinea pigs were not 

 affected by calf pineal substance (dried), but the growth rate 



