314 



E. R. HOSKINS 



It may be noted (see table 3) that thyroid was fed in varying 

 amounts from the negligible quantity of 10 mgms. of dried 

 gland on alternate days to a nearly maximum non-toxic dose 

 of 200 mgms. of dried substance (or an equivalent amount of 

 fresh gland) on alternate days. In all cases no appreciable 



TABLE 3 



Amount and range of dosage employed for each rat in feeding the various groups. 

 The growth in body weight for the 'high dosage^ groups is represented in charts 

 3 and 4. 



Thyroid-fed: 



'Low dosage' 



'High dosage' 



Thymus-fed: 



'Low dosage' 



'High dosage' 



Muscle-fed (controls) 



'Low dosage' 



'High dosage' 



Hypophysis-fed: 



'Low dosage' 



'High dosage' 



Pineal-fed: 



'Low dosage' 



'High dosage' 



SIZE OP 

 SINGLE DOSE 



Dried 

 sub- 

 stance 



mgms. 



10 



15 



7.5 



Fresh 

 sub- 

 stance 



mgms. 

 40 



70 



25 



25 



40 



DOSAGE EMPLOYED FOB 



Females 



Aver- 

 age 

 number 

 of 

 doses 



4.3 

 11.7 



3.5 



16.7 



3.8 

 15.8 



3.5 

 12.5 



3.8 

 17.5 



Range 



4-5 

 10-20 



2-5 

 10-40 



2-5 

 10-40 



2-5 

 10-20 



2-5 

 10-40 



Males 



Aver- 



number 

 of 



1.6 

 16.3 



1.0 

 16.4 



2.4 

 17.0 



2.3 

 18.6 



2.0 

 13.3 



Range 



0.5-2 

 10-20 



0.5-2 

 10-20 



0.5-5 

 10-30 



0.5-5 

 10-30 



0.5-3 

 10-20 



effect upon the growth of the body as a whole was evident. Thy- 

 mus was fed in variable amounts up to 300 mgms. of dried 

 substance, but two individuals receiving twice this amount 

 showed no effects different from the others. Hypophysis was 

 administered in fairly small doses (5 to 100 mgm. of dried sub- 



