340 E. K. HOSKINS 



c. Effects of thymus feeding. In general, the results of thymus 

 feeding were negative. Neither the body as a whole nor any 

 of the individual parts or organs showed any marked or con- 

 stant apparent effect, in comparison with the controls. The 

 apparent tendency to decrease in the relative weight of the male 

 spleen is a doubtful exception. 



The negative results are in agreement with those of Miss 

 Hewer ('14), except as to the degeneration of the testis; but they 

 do not confirm in the rat the stimulating effect upon body growth 

 obtained by Gudernatsch ('12) ('14) and (in part) by Romeis 

 ('15) in amphibian larvae. 



d. Effects of hypophysis feeding. The data in the present 

 experiments show that the weights of the body as a whole and 

 of the various parts and organs of the albino rats in the hypophy- 

 sis-fed groups were even more closely in agreement with the 

 controls than were the thymus groups. The apparent increase 

 in weight shown by the kidneys and thyroid of the females is 

 probably not significant. 



The negative results of the hypophysis feeding in these experi- 

 ments confirm similar findings as to negative effects upon body 

 weight by Caselli ('00); Sandri (anterior lobe )C09); Hoskins 

 ('11); Aldrich ('12a) ('12b); Schiifer ('12); Lewis and Miller 

 ('13), and Gudernatsch ('14). On the other hand they do not 

 agree with Schafer ('09) and Goetsch ('16) who fromveryfew 

 data reported growth stimulated by feeding anterior lobe of 

 hypophysis, nor with the following who obtained retardation 

 of growth (especially skeletal) by hypophysis feeding : Thomp- 

 son and Johnston ('05) ; Etienne and Parisot ('08) ; Sandri ('07) 

 ('09) (posterior lobe); Gushing. and Goetsch (cited by Gushing 

 '12); Wulzen ('14), and Pearl ('16) (anterior lobe). My results 

 likewise disagree with Hallion and Alquier ('08) who obtained 

 hypertrophy of the suprarenal glands, and with Wulzen ('14) 

 who found accelerated involution of the thymus. It may be 

 noted, however, that my dosage was comparatively small sub- 

 toxic, and this might account for the negative results. 



e. Effects of pineal feeding. The pineal groups also agree 

 fairly closely in weight with the control animals, both as to the 



