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E. I. WERBER 



structure. As a serial forerunner of this type of monstrosity 

 may be considered embryos in which one eye is normal while 

 the other is rudimentary (fig. 13). 



As illustrative examples of variation in the degree of the eye 

 defects may further be presented some cases in which both eyes 

 are of unusually small size (microphthalmic) and often located 

 on the dorsal side of the head (figs. 18 to 21). 



b. Defects of the mouth. It is a well known fact that in the 

 Cyclopean or synophthalmic embryos of man and other mammals 

 the nose is almost invariably abnormal in shape, structure and 



Fig. 16 Embryo with one lateral, malformed eye with free lens, I. on eye- 

 less side, from acetone solution (35 cc. gram molec. to 50 cc. sea-water), hatched 

 prematurely on twenty-fourth day after fertilization. 



Fig. 17 Embryo with one normal and one heterotopic eye, h. e., from acetone 

 solution (25 cc. gram molec. to 50 cc. sea-water), hatched prematurely on twentj'- 

 eighth day after fertilization. 



position. It has the form of a proboscis, the nasal passages are 

 more or less blended, a rudimentary septum sometimes being 

 present, while it often may be lacking. Its skeletal parts, if 

 present, consist of cartilage. It is usually situated in the fore- 

 head where it hangs down over the cyclopean eye. 



In many teratophthalmic embryos of my experiments a ^'ery 

 similar deforinity is exhibited by the mouth. The malformation 

 is an unusually striking one. The mouth in the normal embryo 

 (figs. 1 and 10) is broad and flattened and antero-median in rela- 

 tion to the eyes which are situated laterally in the head. In 

 synophthalmic and cyclopean (figs. 2, 3, and 12) and sometimes 

 also in asjanmetrically monophthalmic embryos the mouth has 



