EFFECTS OF DRUGS ON WHITE MICE 147 
2. The mice subjected to tobacco fumes had the largest pro- 
portion of young that died from lack of vitality, 37 per cent dying 
in the first generation, and 26 per cent in the second. Caffeine 
also had an injurious effect, on the viability of the young, 25 per- 
cent dying. Nicotine and alcohol had a less noticeable influence, 
17.3 per cent and 11.1 per cent respectively died in the first gener- 
ation, and 16.6 per cent and 12.5 per cent in the second. None 
of the control young died in either generation. 
3. Out of 707 young born none were deformed, none were 
born dead, and only one abortion occurred. This took place in 
the smoke chamber. 
4. When adult white‘mice were subjected to alcohol, nicotine, 
tobacco smoke and caffeine the growth of their offspring was not 
affected unfavorably. 
5. When both adults and young were subjected to the drugs, 
caffeine had a slightly retarding influence on growth nicotine and 
tobacco smoke had no appreciable effect while the alcohol mice 
grew faster than the controls. 
6. In all the experiments the young of the alcohol mice sur- 
passed all the others in weight. They grew most rapidly when 
they themselves received no alcohol. 
