Experimental Studies on the Development of the Eye. 443 



SUMMARY (aMBLYSTOMA.) 



1. A normal cornea will not develop without the eye. 



2. The size of the cornea varies with the size of the eye, with 

 the area of contact between it and the skin. 



3. Contact between eye and skin is a necessary factor, as an 

 eye separated from the skin by mesenchyme will not cause corneal 

 formation. 



4. The optic cup alone (without the lens) can cause corneal 

 formation. 



5. The lens alone (without the optic cup) can cause corneal 

 formation, provided, as is the case with the optic cup, it is in 

 contact with the skin. 



6. The size of the corneal area over the optic cup or lens is 

 dependent upon the area of contact between these structures and 

 the ectoderm. 



7. It is not necessary that the lens should be first formed 

 from the skin in order to have corneal formation. 



8. The cornea will develop from strange epidermis other than 

 that which normally forms the cornea. 



9. After the cornea is once formed it degenerates and disap- 

 pears after extirpation of the rest of the eye. 



10. The cornea is neither predetermined nor self-differ- 

 entiating. 



11. The cornea is dependent upon the correlation between 

 the eye and the overlying ectoderm for its origin. 



