CONTRIBUTIONS TO THE PHYSIOLOGY OF 
REGENERATION’ 
I EXPERIMENTS ON PODARKE OBSCURA 
BY 
SERGIUS MORGULIS 
Wirnu Seven TextT-FIGURES AND THIRTY-THREE TABLES 
Te Preliminanysstavertent «jie -fa)orc!ecaatevore )oroiess¥etels/eye'e1s/aiainlelilesarelebmie! “tm jefore) aiat-1~)s)©i-lafoinie/olckarial= 595 
Ti Rate of posterior regeneration... ........ ee csc nee ecco eer eee c cette enc eeceeeerare 597 
TIE Phases of posterior repeneration.,...... 0.02 scccerssccseseeen sce srs sceseesscrestes 601 
IV Rate of regeneration after suCCesSiVe OPeratiONs. .. 00.22. ee ee essen cs aewe cer eeeccsnsse 610 
V_ Relation between food-supply and rate of regeneration.........-.++++-+eeeee eee ees 612 
VI Stimulation and depression of protoplasmic activity as dynamic factors in regeneration.... 618 
First series of experiments (alcohol, chloretone)........++++e+seeeeeeeee eee eeeeceee 618 
Second series of experiments (atropine, digitalin).............0eee seen eee eee eee ees 622 
Third series of experiments (strychnine, pilocarpine).........-.+0+e+eeee ever eeeees 628 
VII Concentration and dilution of sea-water as a factor in the rate of regeneration.......... 633 
WAIT (WomipensatlOns.fa..icjsre:e ealciare « ole)» «miele ieie sie el eiote ele nisi wis/ofole/6/e\si= ofnrs/elValalole! = nyeletotaletess ial ste ete 637 
BKC mS UILFIRTL ALY clover eyo) > fois cl olevais elcln stetere\elr! aie ele a\ eta) ohete hele ehahaseVes= tip) <fersretatate) eas] otal sfeletshe eg Cereret ich 639 
DE Bibliopraphy.. so cu ccs ce cae weeny oo wn ie tieinate one wel eiaie vw osiain sm eles emenemiall ie 641 
I PRELIMINARY STATEMENT 
It is, perhaps, a truism to say that the regeneration of an organ 
or of a portion of an organism is the function of the organism as 
a whole rather than of the injured surface alone. Even on purely 
a priori grounds this would appear to be a reasonable and physio- 
logically justifiable point of view. To prove this beyond a doubt 
would, however, be exceedingly difficult, the difficulty arising 
from the peculiarity of the problem. Wherever there are two 
1 This work was started and carried on for two summers at the Marine Biological Laboratory, Woods 
Hole, Mass., and it is a pleasure at this occasion to express my gratitude to the officers of the institu- 
tion for the many courtesies shown me while there. To Dr. F. R. Lillie, the Director of the Labora- 
tory, I am specially obliged for his kindness in affording me the opportunity to pursue this investiga- 
tion. My thanks are also due to Dr. E. L. Mark for reading the first draft of this paper. 
Tue JournaL or ExperiMENTAL ZoOLoGy, VoL. vli, No. 4 
