654. Aa f: Goldfarb 
the nerve has completely disintegrated. Proximally the globules 
of myelin are large and close together, distally they decrease in size 
and number and ultimately disappear completely near the ampu- 
tated end. In other words, the nerve fibers degenerate proximally. 
Above the knee signs of degeneration become more and more faint, 
so that near the base of the leg and within the body as far as the 
spinal column there is no degeneration whatsoever. ‘This account 
holds true for all the plexus nerves. It was further observed that 
degeneration is unequal; fibers in all stages of degeneration are 
found side by side. ‘This, I believe, is due to a difference in the 
rate of degeneration of different fibers, the motor ones breaking 
down far more rapidly than the sensory ones. ‘This difference is 
in all probability the result of destruction of the nerve cell of the 
one fiber and not of the other. 
The following three individuals were preserved sixty-five days 
after paralysis. In each, the nerve cord on examination was 
entirely gone from the lumbo-sacral plexus region and tail. The 
nerves of the hind limbs were substantially in the same condition 
as Nox.5.3. 
No. 1.32 and 1.33. Legs amputated twenty-five days after 
paralysis. Preserved forty days later. No regeneration. 
No. 1.38. Amputated eleven days after paralysis. Parts 
preserved fifty-four days later. The regenerated leg was 3 mm. 
long with 4 toes. ‘This was as much as the fore leg had regener- 
ated in the same time. 
No. 1.58. Hind legs amputated twenty-three days after paraly- 
sis. [he animal was preserved eighty-seven days later. The 
right leg had grown 14 mm., and showed no external differentia- 
tion of toes; the left grew 2 mm., with 4 toes. Sections of the right 
leg revealed the presence of the elements of the new leg, foot and 
toes, though they had not been visible externally. Of especial 
interest are the changes in the nerves. These have completely 
disintegrated near the amputated end. Near the base, typical 
degeneration of the fibers (Fig. 3) extends not only to the base of 
the leg, but within the body about one-fourth the distance towards 
the spinal column. For some distance centrally, the fibers are 
quite normal. But closer to the spinal ganglia, some fibers have 
