STUDIES ON THE EFFECTS OF ALCOHOL, NICOTINE 

 AND CAFFEINE ON WHITE MICE 



II. EFFECTS ON ACTIVITY 



L. B. NICE 



From the Laboratory of Physiology in the Harvard Medical School 



THREE FIGURES 



CONTENTS 



Historical 123 



Methods 125 



The growth of the mice 127 



Weekly activity of the mice 129 



Total activity 139 



Comparison of the total activity of all the mice 143 



Discussion of the effects of alcohol, nicotine and caffeine on the activity of 



white mice 146 



Summary 149 



Bibliography 150 



HISTORICAL 



During the past twenty years the effects of drugs on the activity 

 of men and animals have been studied by many investigators. 

 With but few exceptions however, these studies have extended 

 over short periods of time and the drugs have been given inter- 

 mittently. 



Alcohol 



Hodge ('03) compared the spontaneous exercise of a pair of 

 alcoholic and a pair of control dogs and found that the alcoholic 

 female exercised 57 per cent as much as the control female and the 

 alcoholic male 71 per cent as much as tlie control male. Their 

 activity was measured by means of pedometers in their collars. 



123 



