146 L. B. NICE 



From figure 3 it will be seen that the control line leads through- 

 out the entire time. The nicotine line excels the caffeine line 

 at the sixth week and the alcohol line after the ninth week, and 

 then gradually increases, keeping about an even distance from the 

 control line, until the last two months when it more nearly ap- 

 proaches the control line. The alcohol average excels the nico- 

 tine line for eight weeks, but after that rises much more slowly. 

 The caffeine average equals the nicotine average for five weeks, 

 but after that is the lowest of all. 



DISCUSSION OF THE EFFECTS OF ALCOHOL, NICOTINE AND 

 CAFFEINE ON THE ACTIVITY OF WHITE MICE 



Control line 



The control mice have the highest total activity of all the 

 lines. They also have the highest average maximum. Three 

 of them, Nos. 1, 2 and 4, belong to type 1, having a second period 

 of high activity. These three are well above the average in total 

 activity. No. 3 is less active, coming below the average. It 

 belongs to type 2. It weighed 35 grams while the other control 

 mice weighed 24, 24 and 25 grams respectively. Only one other 

 mouse, caffeine No. 16, weighed as much as 30 grams. There 

 may be some correlation between the inactivity of control No. 3 

 and its weight. None of the controls died. They gained on an 

 average 7.5 grams throughout the experiment. 



Alcohol line 



Of the mice subjected to alcohol three are decidedly below the 

 average in total activity, while one is slightly above it. They all 

 belong to type 2, none having a second period of high activity, 

 as the six most vigorous mice did. Three of them, Nos. 5, 7 

 and 8, start out well, but all except No. 7 rapidly decrease in activ- 

 ity. No. 7 seems to be an average mouse of type 2; however 

 it loses 20 per cent of its weight during the last month. No. 5 

 has a maximum of 125 301 revolutions but decreases very rapidly 

 until its death when twenty-seven weeks old. No. 6 runs low 

 all its life, its maximum being only 86 895 revolutions. It died 



