118 E. R. HOSKINS AND M. M. HOSKINS 



2. The kidney of the second animal was much less severely 

 injured than in the first, as was to be expected since it received a 

 smaller dose and was autopsied sooner 



The glomeruli are seen to be very slightly injured, as is evi- 

 denced by their hyperchromatic and hypochromatic nuclei. A 

 considerable number of secretory tubules show the beginning of 

 either granular or hydropic degeneration. Animal '2' shows in 

 20 per cent of the tubules in the posterior part of the kidney a 

 third type of nephritis that may be called hyaline. It is not 

 seen in the kidney of the first animal. In this type there is a 

 gradual accumulation in the cells of droplets of abright homo- 

 geneous substance which stains readily with eosin. In extreme 

 cases the tubule is completely changed into a mere mass of these 

 droplets. The nuclei may appear normal or hyperchromatic. 

 The hyaline degeneration will be described later. 



e. Liver. There is no serious degeneration in the first animal 

 and almost none at all in the second. In the former a number 

 of nuclei are hyperchromatic and in places the cytoplasm stains 

 poorly. There is a slight congestion in both specimens. The 

 ducts and gall-bladder are uninjured. 



d. Spleen. The spleen was examined microscopically in the 

 first animal only. It is congested, the capillaries and sinuses 

 being somewhat dilated. They contain erythrocytes which 

 appear to be degenerated. In these the nuclei are darkly stained 

 and the haemoglobin appears granular. Some erythrocytes are 

 entirely broken down and are shown only as nuclei surrounded 

 by a few granules. The splenic cells proper and endothelium 

 are intact but some stain poorly. 



e. Spu-al valve (figs. 14 and 15). The spiral valve shows sim- 

 ilar changes in both animals, but the injury in the second is 

 less severe than in the other. 



Both are greatly congested and oedematous. The surface 

 epithelium has completely desquamated in large patches, espe- 

 cially where it is most exposed, on the folds of the mucosa (fig. 

 15). The surface epithelium remaining stains poorly, appearnig 

 dull, and the nuclei are either hypochromatic or hyperchromatic. 

 A few cells are cytolysed. The epithehum in the bottom of the 



