author's abstract of this paper issued 

 bt the bibliographic service, aprii. 11 



HISTOCHEMICAL STUDIES ON THE MECHANISM OF 



RENAL SECRETION^ 



EDWARD J. STIEGLITZ 

 Hull Laboratory of Anatomy, University of Chicago 



SIX FIGURES AND ONE COLORED PLATE 



The minute structure of the kidney required almost three 

 hundred years of investigation before its intricate relations and 

 delicate structure were clearly revealed. As yet the mechanism 

 of urine formation by this highly complex biological apparatus is 

 very poorly understood. A vast amount of work has been done 

 in an effort to throw light upon the subject of renal function, 

 but the results have been so varied, conflicting, and incomplete 

 that we have not as yet arrived at a true understanding of the 

 basic factors. The present investigation was undertaken to 

 analyze the mechanism of renal secretion by means of histo- 

 chemical studies. The work included: 1) A historical survey of 

 the literature having direct bearing on the experimental studies 

 and their interpretation. 2) The development of experimental 

 methods. 3) A series of experiments tracing the course of a 

 salt from the blood stream into the urine by microchemical 

 methods. 4) A series of experiments dealing with secretory 

 curves. 5) A series comparing the different behavior of two 

 salts. 6) An investigation of functional changes in experimental 

 nephritides. 7) A critical consideration of the results obtained. 

 This report will first outline the main problem and then will 

 discuss the various parts of the investigation in the order just 

 given. 



1 This is a report of a series of investigations started in June, 1918, as the 

 basis of a dissertation offered for the degree of Master of Science at the Uni- 

 versity of Chicago (1919), and continued through September, 1920, because of 

 the interest of the work. The author wishes to express his deepest gratitude 

 to Dr. R. R. Bensley for his generous and inspiring guidance and aid. Thanks 

 for aid in some of the technical work are due to Mr. I. D. Siminson. 



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