62 



E. J. STIEGLITZ 



light of the many other indications of secretion by the tubules. 

 Furthermore, such curves correspond almost exactly with those 

 found by Rowntree and Geraghty (55) for phenolsulphone- 

 phthalein, known to be secreted by the tubules. 



The most essential result of these experiments, however, is the 

 decrease in the amount of water passed during the height of the 

 iron elimination and the fact that as soon as there is a fall in the 

 quantity of iron there is a corresponding rise in the volume 

 excreted. This relation was also noted, but not so accurately 

 or conspicuously, in many other experiments in which the urine 



TABLE 1 



KJfS 



was obtained without catheterization, and therefore at more 

 infrequent intervals. Indirectly, such a fall in the volume is 

 further support for the view against the glomerular filtration of 

 iron, as one should expect, an increase in the volume at the 

 height of iron elimination, or an excessively active removal of 

 water back from the uriniferous tubules into the blood would be 

 required. 



Associated with the antidiuresis is the finding that in several 

 of the retention experiments (K72, K87, K89, K102, K105) a 

 condition of ascites was noted at autopsy immediately after 

 the animal was killed. This was especially marked in experi- 



