MECHANISM OF RENAL SECRETION 87 



Furthermore, the ferric iron is active in inhibiting the excre- 

 tion of water. That this is accompUshed through its action 

 upon the cytoplasmic colloids there is little doubt. Were the 

 Cushny theory of renal secretion completely correct, the block- 

 age to water in the cells of the convoluted tubules should greatly 

 increase the volume passed, because the reabsorption of water 

 would be checked. It is obvious that this is not actually the 

 case. But it is equally clear that the urine is concentrated in 

 its passage down the tubules, and we believe this to be accom- 

 plished by the addition of urinary solids, saline as well as nitro- 

 genous, by secretion through the convoluted tubules. If there 

 is any reabsorption of water, as is quite possible, there is little 

 evidence that the convoluted tubules are involved. More 

 likely is it to be associated with the loop of Henle. 



LITERATURE CITED 



1 Bowman 1842 Philos. Trans, mi. 57. 



2 Heidenhain 1874 Arch. f. mik. Anat. Bd. 10, S. 1. 



3 Handbuch der Physiologie (Hermann) Bd. 5. 



4 1874 Pfltiger's Arch. f. die gesammte Physiol., Bd. 9, S. 1, 335. 



5 LuDwiG 1843 Mechanismus der Harnsecretion, Marburg. 



6 Cushny 1917 The Secretion of Urine, Monographs of Physiology. 



7 Kijss 1881 Citrit. nach Beaunis, Physiologie humaine, Paris, T. 2, p. 814 



8 PosNER 1880 Virchow's Arch. f. Path. u. Physiol., Bd. 79, S. 311. 



9 RiBBERT 1881 Nephritis v. Albuminuie, Bonn. 



10 V. SoBiERANSKi 1894-95 Arch. f. exp. Path. u. Pharm., Bd. 35, S. 144. 



11 Brodie Proceedings Roy. Soc, Section B, vol. 87, p. 571. 



12 CuLLis 1906 Jour, of Physiol., vol. 34, p. 250. 



13 Grxjtzner 1875 Pfltiger's Arch. f. d. gesammte Physiol., Bd. 2, S. 370. 



14 LuDwiG 1844 Wagner's Handworterbuch, Bd. 2, S. 637 



15 NussBAUM 1886 Arch. f. mik. Anat., Bd. 27, S. 442. 



1866 Anatomische Anzeiger, Bd. 1, S. 67. 



16 Bainbridge AND Beddard 1906 Bio-Chem. Jour., vol. 1, p. 255. 



17 GuRwiTSCH 1902 Pfluger's Arch. f. d. gesammte Physiol., Bd. 91, S. 71. 



18 Fischer 1915 Edema and Nephritis, John Wiley & Sons, New York. 



19 Heidenhain 1874 Arch. f. mik. Anat., Bd. 10, S. 1. 



20 GxjRwiTSCH Morphologie u. Biologie der Zelle, 192. 



21 Sauer 1895 Arch. f. mik Anat., Bd. 46, S. 143. 



22 Goldmann 1909 Beitr. z. klin. Chirurgie, Bd. 64, S. 192. 



23 1912 Beitr. z. klin. Chirurgie, Bd. 78, S. 1. 



24 Evans 1914 Science, vol. 150, p. 443, March 27. 



25 Quincke 1868 Arch. f. Anat. u. Physiol., Bd. 10, S. 757. 



26 Leschke 1915 Zeitschr. f. klin. Med., Bd. 81, S. 14. 



