182 JOHN STEPHENS LATTA 



It certainly seems as though the presence of a lymphatic plexus 

 in the submucosa is insufficient to account for the extraordinary 

 development of lymphatic tissue in Peyer's patch and the appen- 

 dix, for this plexus is found throughout the small and large intes- 

 tine and the stomach. It is noted that tonsillar tissue is greatly 

 concentrated in and about the caecum. There may be some re- 

 lationship existing between fecal matter in the caecum and 

 appendix and the great development of lymphatic tissue here. 



In discussing the functional possibilities of the intestinal ton- 

 sils, it may be recalled that the lymph vessels of the submucosal 

 plexus form a fairly dense network of capillaries about the nodules. 

 Lymphocytes are found quite abundantly in these vessels. The 

 only source of these lymphocytes could be the lymphatic nod- 

 ules of the tonsils, for there are no entering lymphatics which 

 could carry them on. As the submucosal plexus is a part of the 

 system for transportation of the chyle, it is evident, then, that 

 the tonsillar tissue here serves, in part at least, in forming ele- 

 ments of the chyle. 



GRANULOPOIESIS 



It has already been pointed out that sometimes certain cells 

 with granular content are abundantly present in the connective 

 tissue of the wall of the intestine, especially in the region of the 

 intestinal tonsils in and about the caecum. We are here able to 

 study only the significance of those with acidophihc granules, as 

 the basophilic granules of the mast cells have been dissolved out 

 by the methods of tissue preparation used. Alcoholic fixation, 

 which was found to preserve the basophilic granules, did not fur- 

 nish material upon which their histogenesis could be determined. 



The free eosinophile cells occur in varying abundance in the 

 connective tissue of the submucosa and the tunica propria in the 

 region of the intestinal tonsils, being found, however, most ex- 

 tensively in the deeper portions of the tunica propria, above and 

 between the nodules of lymphatic tissue. They are often found 

 in quite large numbers in the villi, closely associated with the 

 intestinal epithelium, to a less extent in the connective-tissue 

 sheath of the nodules and in the submucosa, and very rarely 



