184 JOHN STEPHENS LATTA 



nous material such as hemoglobin from extra vasated red blood 

 corpuscles (Klein) or products of degenerating muscle (Brown). 



That the eosinophile granules of eosinophile leucocytes are 

 phagocytized exogenous material of a hemoglobin nature is a 

 belief held by many. This theory was followed by Schott, 

 Giitig, Th. Lewis, Badertscher, and many others, but has been 

 most vigorously defended by Weidenreich ('01, '08, '11, etc.). 

 His conclusions were based on observations in hemolymph nodes 

 and the spleen, and also on a series of experiments in which 

 quantities of erythrocytes were injected into the peritoneal cavity 

 of animals, where they undergo degeneration, breaking up into 

 small particles which are phagocytized by large lymphocytes 

 (lymphoid hemoblasts) of the peritoneal cavity and of the taches 

 laiteuses of the omentum (Weidenreich, '08; Schott, '09). 

 In case there is no evidence of erythrocyte fragmentation, which 

 Weidenreich admits is possible, he assumes the hemoglobin is 

 released in solution, absorbed by the lymphocytes, and deposited 

 in them in the form of granules. Badertscher ('13) found elso 

 that fragments of degenerating muscle may be phagocytized by 

 lymphocytes, which then undergo a series of changes to become 

 identical with blood eosinophiles. Some authors consider eosino- 

 philic granules as related to hemoglobin in their nature, but they 

 think are formed endogenously, and not introduced from with- 

 out (Marwedel, '97; Pappenheim, '05). 



Many of the recent investigators of this problem disagree 

 with Weidenreich in his belief that the eosinophilic granules were 

 exogenous material, but consider them true endogenous forma- 

 tions. Even here there is considerable difference of opinion as 

 to the method of formation of the granules. Some (Danchakoff, 

 Weill) thought the eosinophile granules were formed directly 

 as such, appearing in the midst of the basophilic cytoplasm of 

 lymphoid hemoblasts (according to Danchakoff, about the pe- 

 riphery of a slightly acidophilic centrosphere) , the cytoplasm gradu- 

 ally losing its basophilic character as the granules increase in 

 number. Maximow ('10) thought that the eosinophile leuco- 

 cytes were not formed directly from lymphoid hemoblasts, but 

 that first cells with ' pseudeosinophil ' granules were formed 



