DYNAMICS OF HISTOGENESIS 



347 



TABLE I— Continued 



VOLUME OF 



BORIC ACID PUMPED 



THROUGH THE 



URETHRA IN CUBIC 



CENTIMETERS 



6,900 



8,500 

 10, 000 

 15, 000 

 18, 000 

 25, 000 

 30, 000 

 30,000 

 35, 000 

 40, 000 

 45,000 

 50, 000 



REMARKS 



Forced feeding 



Very slight excre- 

 tion of urine 



The common cardiac conditions could be imitated at will. 

 A brachycardia, normal cardiac regularity, tachycardia, extra 

 systoles, group formation, pulsus alternans and ventricular 

 fibrillations could be induced by varying the pressure and by 

 either using or not the mechanical valve between the elevated 

 pressure reservoir and the mercury manometer. 



The bladder of this dog prior to the operation, March 29th, 

 passed an average of 250 cc. of urine in twenty-four hours. On 

 May 20-21, this same bladder passed the enormous volume of 

 50,000 cc. of boric acid during ten hours of experimental obser- 

 vation. This prolonged increase of vesicular pressure prevented 

 the urine from being excreted and set up a uraemic toxaemia 

 which so lowered the resistance of the young dog that it died 

 twenty-four hours after the second operation. On postmortem 

 examination both ureters were enormously dilated with urine 

 and measured 10 mm. in diameter. The nephritic pelves were 

 distended with urine and both kidneys were markedly hydro- 

 nephrotic. The writer intends to present a series of dogs and 

 microscopic demontrations at the next meeting of the American 

 Association of Anatomists. 



Figure 14 shows the manometric curves from the inlet tube 

 of the bladder during the first hour and fifteen minutes of the 



