412 



breadth glands, the ducts {gl. d.) of the latter opening at the bottom 

 of the furrow. 



In the walls of the furrow are seven or more tiers of taste-bulbs 



{t. h.). The bulbs vary in shape, but 

 / most of them possess more or less of 



; a neck. They average about 0,060 mm 



in length and 0,030 mm in breadth. The 

 peripheral ends of the sensory cells 

 (of which there appear to be about 

 sixteen in a well-developed bulb) are 

 highly refractive, and project freely 

 through the pore into the furrow. The 

 t.E: ^-3^' basal half of many of the bulbs rests 



entirely in the mucosa, and is fre- 

 quently bent somewhat downwards. Non-medullated nerves approach 

 the furrow from the sides, and their terminal branches can be followed 

 directly to the bases of the bulbs. 



The organ bears a striking resemblance to the duct of a gland, 

 and doubtless represents the papilla foliata in its simplest form. 

 Amherst, Mass., 11. May 1889. 



^ 



l^. 



Nachdruck verboten. 



The epitrichial Layer of the hnman Epidermis. 



By John T. Bowen, M. D., Boston, U. S. A.. 

 From the histological Laboratory of the Harvard Medical School. 



With 5 figures. 



The investigations, of which this paper offers a brief outline, 

 were begun in October 1887, and have been prosecuted, with few 

 interruptions up to the present time. The subject was brought to 

 my notice by Dr. Charles Sedgwick Minot, with whose kind aid 

 these studies were undertaken, and to whom I am indebted for many 

 valuable suggestions. Dr. Minot had observed in bits of human foetal 

 epidermis, when separated from the corium, stained, and examined 

 with the outer surface uppermost, an outer layer of large polygonal 

 cells, with well marked outlines, and in their center a granular deeply 

 stained body, within which a nucleus could usually be seen. These 

 granular bodies he considered to be the shrunken cell protoplasma, 



