disease, we were finally obliged to look upon them as normal, and 
brought into view by some inherent peculiarity in themselves, that 
rendered them visible in the course of this process of staining. 
To determine if the silver had any portion in their appearance, 
we first stained sections after the method of GoLGI, and having found 
them, cut sections from the same hardened pieces of the liver, and 
examined without any further treatment. These sections only gave 
the usual appearance of the organ hardened in chromic acid salts, 
and showed no large granular cells. Then portions of the same liver 
hardened in absolute alcohol were stained in fuchsin and other aniline 
dyes, both basic and acid, using the heating process of NıssL to obtain * 
the most intense protoplasmic staining possible; but no granular bodies 
were developed; hence the inference was drawn that the prominence 
was owing solely to the treatment with the silver solutions. 
The liver lobuli treated by either method appear with unstained 
hepatic cells clearly visible, with their single or double nuclei in sharp 
outline, holding a few granular particles more refractile to light than 
the nuclear substance. The central portal vein is distinctly seen, the 
inter-lobular vessels and connective tissue are all visible, and tinged 
a faint yellow; the capillary vessels of the lobules are quite trans- 
parent but their outline is definite, and what connective tissue sur- 
rounds them is of such a hyaline aspect as to be ill-defined from its 
very transparency, and only appears as a clear space on either side 
of the capillary. 
Along the margins of these capillaries, numbers of very granular 
cellular masses appear. In the best preparations these bodies seem 
to be regularly scattered over the whole field, usually arranged singly, 
but sometimes in groups of two or three together. Areas where the 
biliary capillaries remain untinged afford the best opportunity to study 
their characteristics, as no other striking object appears in view, all 
other cellular masses remaining uncolored and transparent. Now they 
stand out by their refraction and yellow color as angular or rounded 
granular bodies, of the most irregular forms and bulk, lying close to 
the outer wall of the intra-lobular capillary, between their sheaths 
and the marginal hepatic cells. A large number of the smaller ones 
appear to be simple collections of coarse refractile granules, forming 
irregularly rounded or angular masses, with but infrequently any trace 
of a nucleus, and in size not very much larger than the largest nuclei 
of the liver cells. From this size they gradually increase in dimensions 
until they approximate closely the diameter of the smallest hepatic 
cells, always lying strictly between the capillary wall and the marginal 
