789 
cells, while their prolongations extend along the capillary wall for 
considerable distances, or may be seen passing into the spaces between 
the hepatic cells. In the medium sized and larger ones, nuclei are 
much more frequently visible, usually in rounded or oval form, and 
always single, situated often near the centre of the granular bodies, 
or less frequently, approaching one extremity, the latter being most 
common with the elongated forms. 
The nuclei have two different appearances; they are either more 
transparent and less refractile than the granules surrounding them, 
and with low powers have the aspect of a vacuole, this being common 
with the medium sized masses; or, they may be deeper stained and 
much more finely granular than the rest of the cell body, contrasting 
forcibly with the surrounding granules. Appearances like No. 10 of 
fig. 19, may be here and there found, in which there is the outline 
of a distinct cell, with irregular masses projecting along its edges, 
usually toward the capillary wall. 
The granules composing the cell bodies are very coarse but ap- 
proximately constant in diameter, differing not at all between the 
largest and smallest cells in shape or staining, and not infrequently 
single granules closely approximating them in every way may be seen 
in the walls of the adjacent portal capillaries. These granules within 
the sheaths of the vessels may be seen in every portion of the liver. 
that contain the perivascular cells, and are easily distinguished from 
such cells as encircle the capillary. 
The outline of the smaller and medium sized masses is usually 
more distinct than that of the larger ones; there being invariably a 
line indicating a limiting membrane, but in the largest ones (Nos. 11 
and 12 of the drawings), this is wanting, and the margin is undulating 
though distinct, and all trace of a membrane is absent. 
As already indicated the shape of the majority of the cells con- 
form to the angular spaces left between the vascular wall and the 
undulating line of the marginal liver cells, hence their shape is very 
varied, and no two cells of exactly the same form occur (fig. 21). 
Besides the difference in outline between the larger and smaller 
cells, the position of the first named variety varies occasionally from 
their smaller companions in not being exclusively confined to an in- 
timate relation with the liver cells. While the smaller bodies are 
only found along the intra-lobular capillaries and the intercellular 
connective tissue, the middle and largest forms may once in a while 
be found situated in the connective tissue immediately around the 
sheaths of the central portal vein and along the extreme periphery of 
