791 
nective tissues went; it is not quite clear to our mind but that the 
granular cells were brought into unusual prominence, and the yellow 
staining caused, by some uncommon condition peculiar to the rabbit’s 
organ; we offer for want of a better suggestion, that perhaps they 
had absorbed some unusual digestive product which rendered them 
visible, when under ordinary conditions they are too transparent and 
unstainable to be brought into view by the usual methods of treatment. 
In the unstained sections, the cells of Kuprrer were visible only by 
their vacuolated appearance, but in all the ten or twelve rabbits used 
in the experiment the coarse grained cells were constantly found in 
the same locations. Kuprrer and Rote omit the direct mention of 
the liver of the rabbit from their researches on the star-shaped cells, 
and it may perhaps be possible that the perivascular cells are un- 
usually developed in this animal, and present an uncommonly coarse 
appearance, but we have not sufficient material at our command to 
permit of an extended study in this direction. 
In Kuprrer’s description of the Sternzellen, we find that the 
majority of them have about the diameter of the largest liver cell 
nuclei, but that they are always in measure far behind the average 
of the medium sized hepatic cells. A portion of our granular cells 
are as small as the nucleus of a liver cell, but not an inconsiderable 
number have almost the diameter of the hepatic cellular bodies. 
The majority of the granular cells are undeniably the star-cells 
of KUPFFER, their position corresponds precisely, and is always con- 
stant; standing in direct contact with the portal capillaries, even to 
their encircling the vessel in ring fashion as KUPFFER describes, or 
they may conform to the long diameter of the capillary, or may only 
touch it by a process; and on the other hand their relation to the 
intercellular spaces of the hepatic cells is exactly similar, the granular 
particles pressing in between them. 
With the larger ones, we find cells frequently equalling in diameter 
the smaller hepatic cells, and others encroaching upon the connective 
tissue along the borders of the inter-lobular spaces, where KUPFFER’S 
cells are not usually supposed to penetrate, though their relation to 
the blood-channels continues to be a precisely similar one as in the 
centre of the lobule; and continue to preserve their coarse granular 
appearance, but not the definite outline and appearance of a limiting 
membrane as is the case with the smaller ones. 
These characteristics show that they have a slightly different 
character from the smaller cells corresponding to the star-cells, and 
leads to the supposition that in the liver substance more than one 
