SYMMETRY IN TRANSPLANTED LIMBS 19 
2. Homopleural transplantations, inverted or dorsoventral orienta- 
tion. Thirty-one experiments of this kind were made, with re- 
sults as shown in table 1. Of the twelve cases yielding positive 
results, one^- gave rise to a pair of limbs and the others to single 
limbs in which the asymmetry was reversed; i.e., the right limb 
bud when placed upside down on the right side of the body gave 
rise directly to a left limb. Even in the case which showed redu- 
plication the primary limb of the pair became reversed. In all 
of the cases where limbs resulted, the initial direction of point- 
ing was anterior or dorsoanterior (figs. 10 and 11); i.e., nearly 
the opposite of normal. In four other cases this was also true. 
In only four cases is the direction of pointing recorded as poster- 
ior, and from these nothing definite was developed. All limbs 
which developed continued their growth in the same general 
direction, sometimes being directed more dorsally and sometimes 
more sharply anteriorly (figs. 12 to 17). They also showed the 
tendency to project more directly to the side than the normal 
limbs. The final posture assumed by these appendages varies 
considerably and does not seem to be dependent upon the degree 
of development attained by the appendage. Two cases, each 
having perfectly developed hands, exhibit the following extreme 
conditions : One^^ is practically a perfect mirror image of the nor- 
mal right limb both as regards form and posture (fig. 18). The 
Figs. 10 to 17 Heterotopic transplantation of fore limb; right limb bud to 
right side inverted {hom.dv.), Exp. Tr. E. 219. N, normal limb, right side; TR, 
transplanted limb. X 10. 
Fig. 10 Dorsal view, five days after operation. 
Fig. 11 Lateral view, same age. 
Fig. 12 Dorsal view, eight days after operation. 
Fig. 13 Lateral view, same age. 
Fig. 14 Dorsal view, twelve days after operation. 
Fig. 15 Lateral view of limbs only, same age. 
Fig. 16 Dorsal view, sixteen days after operation. 
Fig. 17 Lateral view, same age. 
Fig. 18 Heterotopic transplantation; right limb to right side inverted {hom. 
dv.), Exp. Tr. E. 139; drawn from specimen preserved twenty-eight days after 
operation. X 10. 
12 Tr. E. 220. 
13 Tr. E. 139. 
