SYMMETRY IN TRANSPLANTED LIMBS 45 
The history of the case in which a limb of original prospective 
asymmetry developed'^ is given on page 126. In this individual 
the limb bud, as it began to grow, pointed anteriorly (fig. (33), 
and continued to grow in that direction. Though it remained 
small and imperfect (fig. (i4), it is clearly a right limb on the 
left side (not reversed). 
The cases which formed reduplications began their de^'elop- 
ment in the same manner. The first direction of pointing is 
recorded as anterior in nine cases, anterodorsal in eight, and 
anterolateral in five. Three are described as pointing dorsally 
and one laterally. Thus these limbs all show in greater or less 
degree the initial effect of their original growth tendency. 
Growth of the bud continues then for some days in a general an- 
terior direction, but sooner or later a reduplicating bud appears, 
usually at the posterior border of the original bud, and this 
grows in most cases into an appendage equal to or exceeding the 
original in size. If the reduplicating bud does not appear 
until late, then the original one may attain considerable size and 
remain, for some time at least, the principal member (figs. 65 
and 66). If it appears earlier, but not until the original bud has 
a good start, then the two members may remain of almost equal 
size (figs. 67 to 71). In other cases, where the reduplicating bud 
begins to grow early, it soon gains the upper hand, and the orig- 
inal may be reduced to an atrophic or rudimentary limb (figs. 
72 to 74). This condition leads over to the single reversed ap- 
pendage in which the original bud is reduced to a spur or nodule 
Figs. 63 and 64 Orthotopic transplantation; right limb bud to left side 
(het.dd.). Exp. R. E. 87. Resulting limb, though defective, is reversed. N, 
normal right limb; TR, transplanted limb. X 10. 
Fig. 63 Dorsal view, seven days after operation. 
Fig. 64 Ventral view of specimen preserved sixteen days after operation. 
■ Figs. 65 and 66 Orthotopic transplantation; right limb to left side [het.dd.). 
Exp. R. E. 96 Resulting limb reduplicated. 
Fig. 6.5 Ventral view, ten daj's after operation; primary limb {PR) points 
into gills; reduplicating bud (Df/), just appearing. X 10. 
Fig. 66 V^entral view, nineteen days after operation; primary member {PR) 
shows evidence of reduplication of hand; reduplicating member (DU) is in 
approximatelj' normal position. X 10. 
*i R. E. 87. 
