SYMMETRY IN TRANSPLANTED LIMBS 49 
palm. One case'- had three almost complete separate appendages 
(figs. 75 and 76). 
Two cases of the nineteen^^ gave rise to an anterior reduplicat- 
ing bud only, which in both individuals was mirrored from the 
ulnopalmar surface. Owing to the position of the reduplicating 
bud in front of the original heteropleural limb, it could not be 
brought into normal posture (fig. 77). 
There remain to be considered the five cases in which the 
asymmetry of the transplanted bud was reversed. These are 
of the utmost interest in showing how a secondary factor (redu- 
plication) may so modify the result that the rules of symmetry 
seem not to hold. They show more than any others the neces- 
sity of having complete histories in each case, for the manner in 
which the end result is reached is of cardinal importance for 
the correct interpretation of the process. As stated above, these 
cases gradate into those in which duplicate limbs arise, so that 
the classification is somewhat arbitrary, the single-limb condition 
being a masked reduplication. Like the others, they begin their 
development with growth of the bud in an anterior direction (figs. 
83 and 86). Then a posterior reduplicating bud makes its ap- 
pearance, and the original bud is rapidly reduced (figs. 84 and 
So and 87 to 89) in relative importance, becoming a spur or nodule 
attached to the latter. The history of a typical case is given on 
page 128. 
Figs. 72 to 74 Orthotopic transplantation; right limb bud to left side (het.dd.). 
Exp. R. E. 74. Reduplication with atrophic primary member. A", normal right 
limb; PR, primary transplanted limb; Dl\ reduplicating member. X 10. 
Fig. 72 Dorsal view, twelve days after operation; the primary limb already 
appears as an appendage of the reduplicating member. 
Fig. 73 Ventral view, twenty-one days after operation. 
Fig. 74 Lateral view of transplanted limb. 
Fig. 74A Dorsal view of same. 
Figs. 75 and 76 Orthotopic transplantation; right limb bud to left side {het. 
dd.). Exp. R. E. 133. Two almost perfect reduplicating members, one anterior 
(A.DU) and one posterior (P.DU) to the primary (PR). The relations of these 
limbs are just as in the diagram, fig. 4B. X 10. 
Fig. 75 Ventral view, eleven days after operation. 
Fig. 76 Ventral view, nineteen days after operation. B, lateral view of pos- 
terior reduplicating member. 
52 R. E. 133, p. 127. " R. E. 120 and 134. 
