SYMMETRY IN TRANSPLANTED LIMBS 55 
developed into reversed limbs. In at least two of the individuals 
reversal was brought about by reduplication. The third is un- 
certain. Of the two cases flo.4 per cent) recorded as develop- 
ing without reversal, only one is clear. The other died at fifteen 
days and was lost, so that the notes made from the living speci- 
men could not be \'erified. 
10. Heteropleural transplantations, dorsoventral orientation. 
Twenty-six experiments were made in this group. In five out 
of the twenty-three individuals that lived the transplanted tissue 
was resorbed, and in two others the resulting appendage was im- 
perfect or rudimentary, so that sixteen positive cases are available. 
Single limbs with reversed asymmetry developed in fifteen, and 
only one gave rise to a duplicate structure (table 2). 
This group of cases shows that from the first the transplanted 
limb buds behave differently from those implanted in dorsodorsal 
orientation. When they begin to become prominent, they point 
dorsoposteriorly in most cases, though sometimes more sharply 
dorsally and frequently more laterally than the normal bud (fig, 
93). As the bud grows, it thus occupies a nearly normal posi- 
tion, though it may continue for some time to project more 
sharply to the side or more dorsally than the normal limb (figs. 
94 and 96). When the third and fourth digits develop, they are, 
however, not formed on the ventral border of the appendage, as 
they would be if the original asymmetry were preserved, but they 
come in on the dorsal border, just as in the normal hand of the 
side to which they were transplanted (figs. 2, 95, 98, 99, and 102). 
The palm of the hand, as in the normal individual, faces the body 
of the larva. Besides the one case in which reduplication actu- 
ally occurred, there were three others in which slight indications 
of doubling appeared, only to disappear later, the more ventrally 
lying bud soon being resorbed. Histories of typical cases are 
given on page 128. 
In all of these cases there was some retardation of development, 
and in some^^ it was very marked. A somewhat greater amount 
of tissue is lost by disintegration when the limb is placed dorso- 
ventrally than when placed otherwise, since the bud does not 
^8 E. g. R. E. 90. 
