SYMMETRY IN TRANSPLANTED LIMBS 57 
The sole case in which a double appendage resulted^ ^ is inter- 
esting, inasmuch as it shows that the primary bud grows into a 
reversed limb, while the reduplicating bud has the original asym- 
metry (figs. 103 to 105). This is the opposite of the result ob- 
tained when the bud is implanted in dorsodorsal orientation. 
(History on p. 129.) 
In the experiments with wounds not cleaned the proportion of 
reduplications is considerably larger — seven out of fifteen, or 
46.7 per cent, as against one case in sixteen in the clean-wound 
group. There were eight cases (53.3 per cent) in which normal 
limbs with reversal of asymmetry developed, as against fifteen 
(94 per cent) in the case of the clean-wound experiments. 
11. The shoulder-girdle in orthotopic transplantations. The 
above account has dealt only with the external features of the 
limb. The shoulder-girdle is likewise of interest. 
As the heterotopic transplantations show, a small portion of the 
girdle surrounding the glenoid cavity always develops in connec- 
tion with the grafted limb. After extirpation of the limb bud, 
however, the outlying regions of the girdle, including the supra- 
scapula and portions of the procoracoid and coracoid, develop 
froln cells that are left in the host."" It was to have been expected, 
therefore, that relations of harmony or disharmony would mani- 
fest themselves in the shoulder-girdle in orthotopic grafts. Study 
of serial sections of some of the cases shows that this is usually 
the case. Twelve individuals, belonging to three different groups 
have been examined in this way. 
The three harmonic grafts (het.dv) all show girdles that are 
normal, except that they are somewhat underdeveloped. There 
has obviously been a union of host and graft tissues to form a 
normal whole, in spite of the fact that the transplanted bud was 
from the opposite side of the body. 
The nine disharmonic grafts all show some form of irregularity, 
and in nearly all cases there is some sort of double girdle with 
reversal of the part that is derived from the graft. The condi- 
tion of the girdle is complicated by the reduplication of the free 
5» R. E. 93. 
«<• Cf. Detwiler, '18, p. 503, and Harrison, 'IS, p. 429. 
