SYMMETEY IN TRANSPLANTED LIMBS 111 
as buds. The reduplicating bud is in each case the mirror image 
of the original, and, when the reduplicating bud is itself doubled, 
then the one next to the original is the mirror image of the latter, ' 
while the one further away is mirrored, with respect to its mate, 
approximately in accordance with Bateson's rule. 
8. Limbs placed in abnormal location, where the specific blood 
and nerve supply is lacking, are frequently resorbed, and when 
they do develop, are usually stiff and functionless, or at best 
show imperfect function. The shoulder-girdle in such limbs is 
reduced in size and the more outlying elements are lacking. 
9. Limb buds placed in normal location (orthotopic) are rarely 
resorbed and nearly always become functional. 
10. Limb buds from the same side of the body normally ori- 
ented in orthotopic position develop normally with but slight 
retardation. 
11. When the limb bud from the same side is rotated 180° in 
its normal location, the results vary considerably, and in the 
majority of cases reduplications occur. The single limbs are of 
two kinds, reversed and normal. The former develop in accord- 
ance with rule 2 (p. 4) , but only one case of this kind has been 
observed, the others that conform to the rules being redupli- 
cated (rule 3). In the other cases the normal position was 
reached by the rotation of the Imib as a whole about the shoulder- 
joint. These cases are exceptions to the rules. 
. 12. Of the twenty-seven cases of reduplications in the above 
group, the original bud grew anteriorly and was reversed. In the 
three remaining cases the primary limb righted itself by rotation 
and the reduplicating member was reversed. 
13. Regulation by rotation usually takes place when at the 
operation the limb bud has been rotated anteriorly over the ' 
dorsal semicircumference not quite 180°. 
14. Limb buds from the opposite side of the body, with the 
dorsoventral axis normally oriented, produced but one unre- 
versed single limb, in accordance with rule 1 (p. 4), the rest 
being reduplications (rule 3) . In one-sixth of the latter the original 
bud, which was disharmonic, was resorbed and remained as a 
small nodule or spur on the reduplicating appendage. The dupli- 
