author's abstract of this papkr issued 



BT THE BlPLIO<:RAPHir SERViCE, MAT 1 



A GENETIC ANALYSIS OF THE FACTORS UNDER- 

 LYING SUSCEPTIBILITY TO TRANSPLANTABLE 



TUMORS 



LEONELL C. STRONG 



Department of Zoology, Columbia University 



THIRTY-THREE FIGURES 



CONTENTS 



I. Introduction 68 



1. Contributions to the genetics of cancer 68 



a. Race 68 



b. Mendelian segregation 69 



c. Mutation hypothesis 70 



2. Factors underlying susceptibility to transplantable tumor tissue.. 71 



a. Race 71 



b. Sex 71 



c. Age 71 



d. Pregnancy 71 



3. Prevalent conceptions concerning peculiarities and characteristics 



of the tumor cell 72 



a. Rhj^thms of growth 72 



b. Virulence or adaptation 73 



c. Transitional conditions 74 



II. Experimental 75 



1. Materials 75 



a. Races used 76 



b. The tumors employed 77 



2. Methods 79 



a. Inoculation and observation 79 



b. Measurement of size of tumor 79 



c. Gonadectomy 81 



3. Results 84 



a. Difference between dBrA and dBrB 84 



b. Constant reaction potentiality 86 



c. Exceptional dBrA 87 



d. Age at inoculation (dBrB) 90 



e. Age susceptibility (dBrB) 92 



/. Age at inoculation (dBrA) 93 



g. Age susceptibility (dBrA) 94 



h. Composite age suceptibility 94 



67 



