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RHODA ERDMANN 



We find after the second day in our cultures: (1) cells of the 

 fibrotjlast type; (2) cells of the 'Riesenzellen' type; (3) cells of 

 the cell culture type, after Foot. All three types can originate 

 from the implanted fat cell. 



Besides these progressive changes we must state that many im- 

 planted fat cells undergo destruction. This is shown by the obser- 

 vation of the living cells as described on pages 79 to 81. Figure 

 4, shows such a disintegrating mass of fat cells from an unstained 

 preparation, and fig-ure 7, shows the mass in a stained prepara- 

 tion. Here two cells of the honeycombed type are recogniza- 



Text fig. B Maximow, 1914, figure 8, plate 3. 

 area of inflammation into a fibroblast. 



Involution of a fat cell in an 



ble (left side, above), one of which is intact, the other has ex- 

 pelled the contents of the plasma. Microlymphocytes are gath- 

 ered around the disintegrating fat masses and the transformed 

 fat cells. Maximow describes how his polyb asts, cells of the 

 lymphocyte order, crowd around the fat cells and destroy them by 

 phagocytosis (page 120). The same phenomenon occurs in the 

 tissue culture; between the second and the fifth day the destruc- 

 tion and resorption of the dying fat cells is finished and the tis- 

 sue culture gradually assumes a different aspect, as will be de- 

 scribed later. 



