86 ELIOT R. CLARK 



4 



vessel-wall is regulated by blood-pressure, has not been tested 

 in these studies. 



In general, my findings are that, while blood- vascular en- 

 dothelium differentiates, develops the power to grow by sprout- 

 ing, and forms a primitive system of arteries, veins and capil- 

 laries as the result of hereditary factors, it very early becomes 

 dependent, for its complete and orderly w^orking out into the 

 elaborate and beautifully proportioned adult vascular system, 

 upon the regulative action of outside factors, to which it reacts 

 in definite ways and upon which it comes to be completely 



dependent. 



BIBLIOGRAPHY ^ 



Arnold, J. 1871 Experimentelle Untersuchungen iiber der Blutkapillaren. 



Virchow's Arch., vol. 53, p. 70. 

 BoBRiTZKY 1885 Entwickelung der Capillargefasse. Centralbl. f. d. medicin. 



Wissensch., vol. 23. 

 Bremer, J. L. 1912 The development of the aorta and aortic arches in rabbits. 



Am. Jour. Anat., vol. 13, p. 111. 



1914 The earliest blood-vessels in man. Am. Jour. Anat., vol. 16, 

 p. 447. 



Clark, E. R. 1909 Observations on living growing lymphatics in the tail of 

 the frog hirva. Anat. Rec, vol. 3, p. 183. 



1912 Further observations on living growing lymphatics: their rela- 

 tion to the mesenchyme cells. Am. Jour. Anat., vol. 13, p. 351. 



1915 Studies of the growth of blood-vessels, by observation of living 

 tadpoles and by experiments on chick embryos. Anat. Rec, vol. 9, 

 p. 67. 



Dareste, Cam. 1877 Recherches sur la production artificielle des Mon- 

 strositc's, Paris. 



Elze, C. 1912 Entwickeln sich die Blutgefjissetamme aus 'netzformigen An- 

 lagen' unter dem Einflusse der mechanischen Factoren des Blut- 

 stromes? Anat. Anzeig., Erganz. Heft, zum, vol. 44, p. 102. 



Evans, H. M. 1909 A On the development of the aortae, cardinal and umbili- 

 cal veins and the other blood-vessels of vertebrate embryos from 

 capillaries. Anat. Rec, vol. 3, p. 498. 



1909 B On the earliest blood-vessels in the anterior limb buds of 

 birds and their relation to the primary sulclavian artery. Am. Jour. 

 Anat., vol. 9, p. 281. 



1912 The development of the vascular system in Keibel and Mall, 

 Human Embryology, vol. 2, p. 570. 



GoLUBEW, A. 1869 Beitrage zur Kenntniss des Baues und der Entwickelungs- 

 geschichte der Capillargefasse des Frosches. Arch. f. mikr. Anatom., 

 vol. 5, p. 49. 



His, W. 1869 Untersuchungen iiber die erste Anlage der Wirbelthiere. Leipzig. 



