222 REMARKS UPON A STATEMENT 
more difficult to detect the cell-shaped and more rounded globules, 
although they are quite as certainly present. When the object has 
not been at all damaged, the cells, and especially the pigment-globules 
adhering to the outside, exhibit an arrangement like that of the vege- 
table cells in general, and particularly in the earliest stages in the 
formation of the leaf, that is, a disposition corresponding to spiral lines 
projected on the surface in accordance with the strictest rules) 
——compared to the cellular tissue of plants, I chose, expressly 
(l.c. 77. Each of these globules (ganglion-globules), wherever ob- 
served, has an external, more or less distinct, areolar tissue-like envelope, 
and contains a parenchymatous mass proper to itself, an independent 
nucleus or kernel (nucleus oder Kern), which again encloses a 
second roundish, transparent nucleus)——on account of this re- 
semblance in form, the uniform appellation of the nucleus 
(Kernes), just as I afterwards described the nucleolus which was 
observed by me. (Repertor. i, 143. In every cell without exception 
there is a somewhat smaller and more compact nucleus of a round or 
oval form. It usually occupies the centre of each cell, consists of a 
minutely granulous substance, but encloses a well-defined, round cor- 
puscle, which thus forms a sort of second nucleus within it.) Jn the 
study of the epithelia, prosecuted particularly by Henle and 
myself, there was no want of analogies with vegetable cellular 
tissue, the individuality of the cell-parietes was also distinctly 
demonstrated. (Ib. 284. Roundish, hexagonal, flat, aud tolerably 
thin cells lie (in the external skin of the proteus) close upon one 
another, disposed in regular arrangement, and always connected 
together with their lateral edges and angles in mutual correspondence. 
The interior of these delicate bodies is filled by a granulous or yel- 
lowish mass, which represents a sort of nucleus. But the separate 
granules of this nucleus, however closely they may he together, may 
be accurately distinguished from one another. With a very strong 
magnifying power, each one of these granules may be seen to be more 
transparent in its centre than it is in its periphery. It may then 
also be most distinctly ascertained, that the somewhat delicate parietes 
of each cell are perfectly isolated from the central cavity. No trace 
of granules or fibres can be observed on the walls themselves ; there is 
merely a clear, transparent, vitreous, and homogeneous mass.) J had 
also remarked that the nuclet (pigment-vesicles) were the parts 
first formed in the pigment of the choroid coat (Entwickelungs- 
geschichte, 194. The following is the mode in which, according to 
my observations, the stratum of pigment is formed in man, mammalia, 
and birds; separate, round, colourless, and transparent corpuscles are 
first deposited upon the internal surface of the substance they are to 
cover, in the earliest period (up to the tenth week) these corpuscles in 
the human subject measure from 0:000355 to 0:000405 Paris inch in 
diameter. They are the future pigment-corpuscles or pigment-vesicles. 
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