140 ' HALSEY J. BAGG 
as three young were born December 11th, fertilization took place 
about fourteen days after the treatment. ‘Two of the young were 
apparently normal, but one showed a large haemorrhagic area, 
which involved most of the right side of the snout, the right eye, 
and a portion of the lower jaw on that side. This area disap- 
peared after three days. Female 99, injected and mated at the 
same time with female no. 85, received a dose of 5.6 me. Five 
young, three males and two females, were born on December 13th, 
making the date of fertilization about sixteen days after treat- 
ment. One male and one female showed definite haemorrhagic 
areas on the face. Consideration of these cases will be deferred 
until later. 
Seventeen females following treatment were killed at varying 
intervals after mating and showed markedly haemorrhagic or 
cystic ovaries and congested uteri. In these cases radium emana- 
tion apparently had either so altered the maternal tissues as to 
prevent fertilization or development when started was soon 
followed by the death of the embryo and its absorption. Many 
nodules were found in the uteri in which it was impossible to 
differentiate between embryonic and maternal structures. 
The remaining females (as previously stated, eleven died 
between the period of treatment and mating) produced either 
full-term normal young or young apparently normal at autopsy. 
Several of these living young grew normally and were mated 
inter se, but produced no abnormal offspring, although observed 
for two generations. 
III. Intravenous injections after mating. The intravenous 
injections were primarily planned to act as a check on the series 
of subcutaneous treatments. The object was to determine the 
immediate reactions that might occur in the embryo as a result 
of injecting a comparatively large dose of radio-active solution into 
the circulation of the pregnant female, and whether these re- 
actions would be similar to those already recorded for the sub- 
cutaneous series. ‘The toxic reactions were so prompt and fatal 
that it was not necessary to treat many animals to settle this 
point. A typical case in that of female no. 123. ‘I his animal, 
of about nineteen days’ pregnancy, was treated with 30 me. 
