RADIUM IRRADIATION AND DEVELOPMENT lao 
gamma-ray radiation, produced marked areas of extravasation in 
the subcutaneous connective tissue of the developing young. 
This suggests that the action of radium emanation might be 
selective upon the endothelium of blood vessels. 
5. Extravasations occurred in the developing young of females 
treated with radio-active solutions a considerable time before fer- 
tilization, and suggest that in some way the faculty of the later 
developing embryos to form proper blood vascular endothelium 
had been interfered with. 
6. The results so far obtained indicate that gamma-ray radia- 
tion is a physical agent admirably adapted to the study of experi- 
mentally produced developmental arrests in mammalian embryos. 
7. When women are subjected to therapeutic irradiation, 
especially during the early stages of pregnancy, the clinician 
should be forewarned concerning the possibility of producing very 
grave disturbances in the developing child. 
LITERATURE CITED 
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2 PrertHEs, G. 1904 Versuche iitber den Einfluss der Réntgenstrahlen und 
Radiumstrahlen auf die Zellteilung. Deut. med. Woch., Bd. 30, 8S. 632. 
3 Hertwic, P. 1911 Dureh Radiumbestrahlung hervorgerufene Verinder- 
ungen in der Kernteilungsfiguren der Kier von Ascaris megalocephala. 
Archiv. f. mikros. Anat., Bd. 77, No. 2, S. 301. 
4 Scuapger, A. 1904 Experimentelle Untersuchungen iiber die Wirkung des 
Radiums auf embryonale und regenerative Entwicklungsvorgiinge. 
Deut. med. Woch., Bd. 30, 8. 1434. 
Hertwia, O. 1911 Die Radiumkrankheit tierischer Keimzellen. Archiv. 
f. mikros. Anat., Bd. 77, No. 2, S. 1. 
6 Hertwia, G. 1911 Radiumbestrahlung unbefruchteter Froscheier und ihre 
Entwicklung nach Befruchtung mit normalem Samen. Archiv. f. 
mikros. Anat., Bd. 77, No. 2, S. 165. 
Prertues, G. 1904 Versuche iiber den Einfluss der Réntgenstrahlen und 
Radiumstrahlen auf die Zellteilung. Deut. med. Woch., Bd. 30, 8. 668. 
S Gruman, P. K., anp BAartser, F. H. 1904 Some effects of the Réntgen rays 
on the development of embryos. Amer. Jour. Physiol., vol. 10, p. 222. 
9 Baupwin, W. M. 1919 The artificial production of monsters conforming 
to a definite type by means of x-rays. Anat. Rec., vol. 17, no. 3, p. 135. 
10 Baae, H. J. 1920 Pathological changes accompanying injections of an 
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il, Joy The 
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