No: 3-] SLODYV (OF 2HE NERVE CELE. 455 
Nucleolus of control was seen at first to change from crescent- 
shaped to round, in which condition it remained. 
No. oF PosITION OF NorMAL Le a, : . 
ing DATE. Cott. SoLuTION USED. SHRINKAGE IN VOLUME OF NUCLEUS. 
1.36 0.30 
32 Aug. 28 Io cm. Same solution. 39 % 
Behavior of nucleolus sim- 
ilar to 31. 
2.45 0.30 
33 Aug. 28 Io cm. Same solution. 30 % 
Behavior of nucleolus same 
as in 31 and 32. 
The most striking feature of the table is perhaps its great 
irregularity, the lack of any apparent relation between amount, 
duration, or intensity of stimulation and effect in change of 
nucleus. This is in apparent disagreement with results of 
former work, in which a quantitative relation between stimulus 
and shrinkage of nucleus is evident. It is, however, easy to show 
that the lack of agreement is only apparent. In the former experi- 
ments we were dealing with definite amounts of stimulus given 
in the same way to corresponding nerves which, in turn, led the 
stimulus to corresponding ganglion cells. The point to be 
emphasized is that the cells were in position in the body under 
practically the same conditions of blood supply, and in similar 
relation to the stimulus. In the present series, the cells are 
removed from the body, placed in a stream of solution which it 
is impossible to make equal to the different cells, and in an 
electric field the intensity of which in any point it is impossible 
to regulate or even estimate. Taking these important variables 
into account, the evidence for quantitative relations between 
stimulus and effect is possibly as strong as we should expect to 
find it. The measurements from which the percentages in the 
table were computed were made, long and short diameters of 
nucleus as usual, with no thought beyond accuracy of each 
measurement. 
Differences and similarities between different experiments 
may be seen more clearly by plotting the percentages in the 
table in the form of curves. This was done for all the experi- 
ments. Four of the most comparable of the curves are repro- 
duced in Fig. 3, drawn from experiments 18-21. Position of 
coil and solution are the same in these experiments, yet the 
course run by each cell in its fatigue is distinct, though similar 
in character. By far the majority of the curves are of the 
