456 HODGE. [Vor 
same general form. They show that the cell tires rapidly at first, 
then more gradually, to a condition of fatigue, complete, at 
least, so far as our present method is able to indicate. This is 
also in apparent variance with curves derived from a former 
series of experiments, in which fatigue was rapid at first, then 
gradual, then more rapid again. A slight tendency to this 
form of curve is found) in ‘experiments 6,°S, 9," 15; 235) these 
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all showing slight secondary acceleration. Considering the 
circumstances of the two series of experiments, no correspond- 
ence can be expected. In the present series, the cells are mot 
living in a nutrient solution, but in a normal non-nutrient solu- 
tion which is able, in all probability, to carry off by diffusion 
waste matters of the cell’s metabolism. Consequently the 
nucleus shrinks more rapidly, and also more continuously, to a 
condition of complete fatigue. As more fully discussed in a 
previous paper, there are reasons for believing that cells in 
