460 HODGE. [Vou. IX. 
series of plates drawn from the living specimen. This has not 
been done, because I do not feel that my study of cell granula- 
tion and its changes during fatigue is at all complete. Hence 
for the present the accompanying outline drawings, reproduced 
from camera outlines made during the experiment, may suffice. 
Fig. 4 represents experiment 23, 1 to 7 being successive draw- 
ings of the stimulated cell. 
To begin with, we have a typical spinal ganglion cell with 
nucleus situated eccentrically. The nucleus is clear, slightly 
oval in shape, but with perfectly even contour, as seen in 
optical section. After thirty minutes stimulation, 2, Fig. 4, the 
side toward centre of cell has changed, the outline here having 
become faint and indented. In 4 the other side has begun to 
cave in, and so to 7, where we see a shrunken jagged nucleus 
one quarter its original size. It has come to he a little closer 
to the cell capsule, and the cell has not decreased in size to a 
measureable amount. To enter here more into detail would 
be to repeat a former description. The experiments are in 
fact repetition of former work under conditions varied so that 
we see continuously and in a single cell what we were able to 
find in a series of different animals and months of experimenta- 
tion before. Placed in osmic acid the nuclei retain this appear- 
ance, which fact completes connection with former work done 
by the osmic acid method. It should be added, however, that 
the characteristic darkening of the nucleus as it shrinks does 
not occur in these experiments. 
Considerable attention was directed toward studying changes 
in the granulation of protoplasm during stimulation. Some of 
the cells became lighter and clearer. In others this was not 
so manifest. In experiment 3 the cell under observation con- 
tained several prominent oil droplets. During the first two 
hours one of these was observed to become smaller and smaller, 
and at last it disappeared. Two more, observed at first to be 
separate, were seen to have moved together and to coalesce. 
Teased in glycerine, after treatment with osmic acid, the 
cell-protoplasm is seen to be pervaded by large irregular 
light spaces, probably the vacuoles observed in sections. 
The entire cell is, however, too thick for such study. It 
