230 The Effect of Fatigue on Muscle Nuclei 
of fatigue could be demonstrated in the nuclei. The result is not a 
surprising one when we consider the. power this tissue has of recovery 
from: katabolic changes. 
SUMMARY. 
The following changes are demonstrable in the nuclei of muscle cells 
as a result of activity: 
1. The nuclei are shrunken and present a very irregular outline. 
This shrinkage and distortion increases with the length of the stimuli 
up .to a certain point when no further visible change is shown, no 
matter how long and severe the fatiguing process. 
2. The nuclei of fatigued muscle cells are less densely granular and 
take stains less deeply than the nuclei of resting cells. 
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