Richard Mills Pearce _ 453 
Hirschfeld’s description the islands are not mentioned. Schlesinger, 
(14), Ssobolew, (9), and Opie, (15), however, call attention to their per- 
sistence in even the most advanced examples of sclerosis. 
I have studied the pancreas of 
congenital syphilis for the pur- 
pose of obtaining evidence of 
arrested development of the 
islands. The increase of con- 
nective tissue isolates these 
structures so distinctly from the 
remnants of glandular tissue 
that their relations may be 
readily studied. In six cases 
examined, I found frequently a 
persistence of the solid mass of 
cells connecting the island with 
the acinus.’ I believe that this 
appearance represents the ar- 
rested development of the island 
at the period corresponding to 
preparation No. 10. At this 
period (third month) — the 
amount of connective tissue in 
Fia. 3. Syphilitic pancreatitis in a foetus of 
h l a pi the seventh month. Arrested development of 
the norma pancreas 18 Very the island; the persisting solid process of 
d i id lif cells still connects the island with the glandu- 
great, and the rapid prolifera- laracinus. 
tion of the glandular portion of 
the pancreas characteristic of the fifth and sixth months has not com- 
menced. 
Syphilis of the pancreas has been observed as early as_ the 
fifth month (Miiller, 16), but there are no observations to prove that 
it does not occur earlier. The increase of connective tissue, which is 
the characteristic lesion in the pancreas, causes not only an atrophy 
of existing glandular structures, but what is more important, prevents 
the further development of the gland. The glandular tissue is repre- 
sented by small, irregularly scattered gland groups; the ducts are promi- 
nent; the islands are arrested at the stage in which they are still con- 
nected with the acini. The microscopic picture of the normal pancreas 
at the end of the third month is very similar to the syphilitic pancreas 
1Opie, in his account of two cases of congenital syphilis, describes and pictures 
this condition. 
31 
