296 J. S. FERGUSON 



not blacken, but take on a characteristic golden brown color; 

 nevertheless, in certain locations and under certain conditions 

 some fibers which we have been accustomed to regard as collag- 

 inous, e.g., within dense connective tissue bundles or in embry- 

 onic mesencyhme, do blacken somewhat, though never so typically 

 nor with such clear and sharp definition as do the fibers of "reticu- 

 lum" in mature tissues. The further elucidation of this atypical 

 reaction of the collaginous fibers must be sought in the histogen- 

 esis of the connective tissues. For the present we may safely 

 consider the black reaction of fibers of mature connective tissue 

 to the Bielschowsky stain to be distinctive of "reticulum" in all 

 satisfactory preparations, viz. those in which the collaginous 

 fibers assume a golden brown tint. 



When such tissues as nerve, muscle and embryonic mesenchyme 

 are excluded the Bielschow\sky method serves as a well-nigh 

 specific stain for the reticulum of Mall. 



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