516 GENCHO FUJIMURA 



Ebstein and Griitzner, '74; Lavdowsky, '76; Langley, '79 to '89 

 Mathews, '80; Klein, '82 ; Biedermann, '82 and '86; Flemming, '82 

 Klihne and Lea, '82; Nicoglu, '93; Altmann, '94; Galeotti, '95 

 Krause, '95 and '97; MuUer, '96 and '98; Solger, '96; Zimmer- 

 mann, '98; Held, '99; Maximow, '01; Noll, '01; Fleischer, '04; 

 Heidenhain, '07; Babkin, Rubaschkin, and Ssawitsch, '09. 



I will not go to the trouble of giving a detailed account of each 

 of the results of these research works, but will confine myself 

 to summarising the main points of their investigations respecting 

 the structure and secretory phenomena of glandular cells, which 

 are most essential to my studies, and refer to the original works 

 for details. 



In the first place, the structure of the glandular cells having 

 a duct, or externally secreting glands, greatly differs, as is gener- 

 ally well known, according as they are serous or mucous. The 

 serous cells have an exceedingly large number of granular 

 bodies, and consequently their characteristic is that they are 

 generally dark. These granular bodies are generally known as 

 CI. Bernard's secreting granules. The relation which the latter 

 has to secreting functions has been generally recognized by 

 many an interesting research work since that of R. Heidenhain, 

 and it will be noted that Heidenhain, having observed a kind 

 of slender thread-like structure which exists close to the base- 

 ment membrane, of the glandular cell of a dog's pancreas, for 

 the first time drew general attention to a peculiar sort of organic 

 structure which is existent in the glandular cell. This kind of 

 thread-like structure was demonstrated also in the salivary 

 ducts and convoluted uriniferous tubules in after years, and it 

 cannot be anything but ]M. Heidenhain's so-called 'Basal- 

 filamente' or our plastosomes. 



Below I wish to give a general outline of the changes appear- 

 ing in these organic tissue elements of the glandular cells which 

 will follow the secretory functions. 



Now, at first, it is universally agreed by every author that 

 secretory granules increase or decrease according to secretory 

 functions. According to the result of the close examination 

 with respect to such correlation, conducted chiefly while in a fresh 



