520 GENCHO FUJIMURA 



ments. And the three authors mentioned above are of the 

 opinion that the several bodies which are revealed by this 

 secreting form may be compared with the small bodies which 

 are often known as ' Nebenkerne, ' 'parasome, ' 'corpusculus 

 paranuclaires, ' and 'noyau accessoir' in the pancreas cells of 

 the lower vertebrates. 



Fifth form. This points to a case in which the substance of 

 secretory granules changes its quality at a certain period, be- 

 comes soluble, and is only dissolved in the watery part of the 

 secretion alone, as w^as instanced by Babkin, Rubaschkin, and 

 Ssawitsch, in the experiment of the pancreas secretion after 

 pouring acid in the duodenum. As a proof thereof, the secretion 

 always shows in this case the same coloring reaction as do the 

 zymogene granules. 



The three forms (the third to the fifth) described above are 

 together met with in the pancreas cells, and it deserves special 

 attention that according as the cause differs for the rise of se- 

 cretion, even in one and the same glandular organ, there is a 

 difference in the forms of secretion, and consequently in the 

 nature of the secretion produced. 



Sixth form. Certain secretory granules sometimes have 

 two extreme developments. As an instance, M. Heidenhain 

 observed the skin glands of a salamander and he found that, 

 as the development of the granule reaches a certain degree, one 

 part of it is liquefied and passes into a viscous secretion, while 

 the other goes on growing in size, and is perfected into the char- 

 acteristic poison grains. 



Seventh form. A certain organic structure is presented in 

 the secreting granules; at the beginning it is not different 

 from ordinary cases, and yet as a certain development is 

 accomplished, every granule is divided into a crescent-shaped 

 section (Kapuze) which is stainable, and into an unstainable 

 section (Trager) within the crescent-shaped section, thus forming 

 the ' Halbmondkoperchen ' so termed by M. Heidenhain. This 

 latter as it grows in size is considerably enlarged, especially 

 in the Trager, and consequently the Kapuze is flattened gradually 

 and is only stuck like a plate on its one side. Then the Trager 



