15 



relation with the reticulum. The granules are coarse and are fixed 

 by various reagents including boiling alcohol, though rendered soluble 

 by alcohol at ordinary temperature. They stain with acid and also 

 with certain basic stains. They are neither pure fat, nor albumoses, 

 but give some reactions characteristic for peptones. They are most 

 numerous in the jejunum and ileum, less so in the large intestine. 



4) The granule cells of the mucosa stand in no definite relation 

 to the lumen of the canal, to the crypts, to any lamina, or to the blood 

 or lymph vessels. 



5) The acidophiles are closely related to certain granule cells in 

 the blood as to staining properties, but are not identical with them. 

 They difter from them also in nuclear structure. Finely granular baso- 

 phile cells also occur in the blood, but no coarse basophiles like those 

 of the intestinal mucosa. 



6) The basophiles belong to the same class as the coarsely gran- 

 ular basophile cells described by Hardy and Westbrook in the 

 intestinal mucosa of certain other vertebrates. They are similar to 

 Ehrlich's mastcells, though different from those of many authors, as 

 shown by their solubility in water after alcoholic fixation. 



The acidophiles are similar to the coarsely granular oxyphile cells 

 of Hardy and Westbrook, and probably represent a variety of the 

 eosinophile granule cells so widely scattered throughout the body. 



References to Literature. 



1) Bekgonzini, Ueber das Vorkommen von granulierten basophilen und 

 acidophilen Zellen im Bindegewebe und über die Art, sie sichtbar 

 zu machen. Anat. Anz., 1891, p. 595 — 600. 



2) Ehrlich, P., Beiträge zur Kenntnis der granulierten Bindegewebs- 

 zellen und der eosinophilen Leukocyten. Arch. f. Anat. u. Physiol., 

 Physiol. Abteilung, 1879, p. 571—579. 



3) Hardy, W. B., and Westbrook, E. F., The wandering cells of the 

 alimentary canal. Journ. of Physiol., Vol. 18, 1895, p. 490 — 524. 



4) Heidenhain, R., Beiträge zur Histologie und Physiologie der Dünn- 

 darmschleimhaut. Pflügers Arch. f. d. gesamte Physiol., Bd. 43, 

 Suppl. 1888. 



5) Kanthack, A. A., and Hardy, W. B., Morphology and distribution 

 of the wandering cells of mammals. Journ. of Physiol., Vol. 1 7, 

 1894, p. 81—119. 



6) Krompecher, E., Beiträge zur Lehre von den Plasmazellen. Beitr. 

 z. path. Anat., Bd. 24, 1898, p. 163. 



7) MuRLiN, J. R., Absorption and secretion in the digestive system of 

 the land isopods. Proc. Acad, of Natural Science of Philadelphia, 

 1902, p. 284—359. 



