reticulum, apparently becoming a part of it. Other granule cells lie free in 

 the meshes of the connective tissue reticulum. The round cells are from 

 5 to 6 micra in diameter; the spindle-shaped ones 16 to 18 micra 

 long. The nuclei in some cases stain very faintly, the granules stain- 

 ing metachromatically. In such cases the nuclei are spherical, 2 to 

 3 micra in diameter, and sharply defined. In other cases the nuclei 

 seem to be very deeply stained, but owing to the close aggregation 

 of coarse granules about them, I am unable to decide positively 

 whether the nuclei are the same as those mentioned above and the areas 

 made to appear dark from the number of granules over them, or 

 whether the nuclear material itself stains. I think that the position 

 of the granules alone does not make the difference in appearance, for 

 the cells with clearly defined nuclei also have the granules most nu- 

 merous near the nuclei. That the nuclei may be different is also to 

 be inferred from the character of the nuclei of non-granular connective 

 tissue cells in the same sections. Some of the latter have nuclei stain- 

 ing only faintly, taking the stain less than the finely reticular cyto- 

 plasm of the cells; others have large masses of deeply staining chro- 

 matin lying about the periphery in six or seven clumps, and almost 

 filling the nucleus. Evidently, if such types of cells had granules 

 aggregated about their nuclei, they would give the two appearances 

 here seen. I am strongly inclined to think, therefore, that there are 

 two different classes of nuclei of the basophile cells. The basophile 

 granules are always most numerous near the nuclei, but occur abund- 

 antly far out in the cell processes. In some cases they almost com- 

 pletely fill the cell bodies (in the round or oval cell), in others they 

 are less numerous but are never few. The granules vary from one- 

 fourth to one-half micron in diameter. 



The solubility of the granules in water after alcoholic fixation is 

 characteristic also for the mastcells of Ehrlich (2) ; this point, however, 

 distinguishes them from the basophile granule cells described by many 

 writers, including the mastcells of Westphal (12), the basophile cells 

 of Bergonzini (1) which were stained in aqueous solutions, Unna's (10) 

 plasmacells which also stained in aqueous solutions, and the plasma- 

 mastcells of Krompecher (6). 



Acidophile Granule Cells. 

 The acidophile cells are preserved by all the fixatives tried except 

 the alcohol-acetic and the alcohol-sublimate-acetic, viz: absolute alco- 

 hol, 2 \ potassium bichromate, Zenker's fluid, 10 % formalin, picric 

 acid, saturated solution of corrosive sublimate containing 0,6 % sodium 



