19 



plasm, erythrocytes singly aud in groups, as well as masses of free 

 haemoglobin and haemoglobin crystals, and pigment in granules and in 

 crystalHne clumps. The inference which Browicz is led to form from 

 the facts which he has recorded is expressed in the following words ^) : 



"Alle diese angeführten Umstände veranlassen den Verfasser, 

 außer den intracellulären Gallengängen als Ausfuhrwege noch die 

 Existenz besonderer Einfuhrvvege, Ernährungswege oder Kanälchen, in 

 den Leberzellen anzunehmen. 



Daß dieselben nicht als ein System von evidenten Kanälchen 

 sichtbar gemacht werden konnten, thut dieser Annahme keinen Ab- 

 bruch. Die intracellulären Kanälchen überhaupt müssen ja selbstver- 

 ständlich äußerst fein sein, welche selbst unter günstigeren Verhält- 

 nissen nur teilweise, gleichsam stückweise sichtbar werden, besonders 

 wenn man die sehr geringe Quantität von Ernährungs- und Functions- 

 material, welches in einer Zeiteinheit in die Leberzelle hineingelangt, 

 berücksichtigt; das mikroskopische Bild der Zelle ist ja nur ein Augen- 

 blicksbild". 



The objective proof of the existence of the intracellular canaliculi 

 and their connection with the lobular capillaries which Browicz has 

 inferred from the presence of erythrocytes within the liver cells (an 

 inference which is confirmed by the intimate anatomical connection which 

 he has further shown to exist between the cells bounding the capil- 

 laries and those of the ])arenchynia of the lobules) is furnished in a 

 striking manner in a preparation of rabbit's liver, injected with carmine- 

 gelatine from the portal vein, which I have come across in the histo- 

 logical collection belonging to the Physiological Laboratory of the Uni- 

 versity of Edinburgh. In all sections from this liver there is seen 

 within the protoplasm of the cells — but not within the nucleus — 

 a network of fine varicose canaliculi filled with the red injection and 

 communicating here and there directly with the lobular capillaries, 

 which are also completely injected. These is nowhere any sign of 

 diffusion of the carmine — the nuclei are completely colourless — and 

 only here and there of extravasation of the injecting material between 

 the cells, which at such places do not show the canaliculi in question. 

 The gelatine mass has not passed into the cells by way of the bile 

 ducts or perivascular lymphatics for these show no signs of being in- 

 jected. The injection is in fact limited to the bloodvessels and the 

 intracellular channels, but the efferent lymphatics of the portal canals 

 contain diluted injection-material. The intracellular canaliculi are not 



1) Bull, intern, de I'Acad. d. Sc. de Cracovie, Juillet 1899, p. 369, 370. 



2 * 



