300 



strongly basophilic in staining reaction. Sometimes these granules are 

 densely packed and the mass is sharply circumscribed. When less 

 regular in form the masses assume elongated and crescent shapes. 

 Usually the masses are multiple and situated just beneath the nucleus 

 (Figs. 4, 8). When crescentic they partly encircle the nucleus either 

 from below or from one side. Sometimes they lie free in the vacuoles 

 or they may be closely surrounded by the cytoplasm. After staining 

 with thionin, methylene blue or muchaematin, these bodies yield a 

 typical mucin reaction. But they are almost equally conspicuous after 



simple staining with hematoxylin 

 and eosin. As far as staining 

 reactions can be conclusive in 

 the case of mucinous materials, 

 these bodies are proved to be 

 mucin accumulations, but whether 

 they are normal secretory pro- 

 ducts of the cell or the result 

 of beginning degeneration is un- 

 certain. 



One sees everywhere in the 

 connective tissue, cells whose 

 nuclei are fragmented, undoubted 

 evidence of karyolysis. These 

 cells belong to both connective 

 tissue and the blood. Among 

 the accumulations of blood cells 

 in the vessels are similar cells; 

 these degenerating cells are slightly 

 larger than the normal cells. The 

 blood corpuscles are all of the 

 nucleated type , erythroblasts. 

 Among accumulations of the blood 

 cells are found everywhere the 

 three types: normoblasts, micro- 

 blasts, and megaloblasts. Many 

 are found in process of division, containing two or more rounded 

 nuclei. In cases where two nuclei are present in a single cell, they 

 may be of equal or unequal size; where three are seen, two are 

 small, one large; where four are found, they are of approximately 

 equal size. The process of division seems to be amitotic. However, 



Fig. 8. Section of entodermal wall 

 showing mucinous masses (o) in proximal 

 portion of cell ; n nucleus of entodermal 

 cell with three nucleoli ; b fat vacuoles. 

 Stain, thionin; thickness, 10 micra; Camera 

 lucida, X 750. 



