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fat-cells are of various sizes and shapes. Some have the small, drawn out 

 nucleus on one side, while others have none. The large spaces between 

 these fat - cells is noticeable and unusual ; but the most conspicuous 

 feature has to do with the nuclei. They are very numerous, more 

 than are needed for a normal tissue and very small. Figure 4a is a 

 drawing of a nucleus as normal as could be found. It was taken from 

 a region unaffected by the hemorrhage. But most of the nuclei are 

 like those in Figure 4 b, about one-fifth the size of the normal nucleus 

 and roundish in outline. Apparently there has been a rapid prolifer- 

 ation of these nuclei in the diseased tissue. A little study with the 

 oil immersion lens revealed the manner of the multiplication of these 

 nuclei. No mitotic figures were found at any place; but many such 

 stages as shown in Figure 4 b and c, where the nuclei are dividing 

 amitotically. The process continues until each nucleus becomes a very 



Fig. 4. a. normal nucleus, b. amitotically dividing nuclei, c. further divisions. 



small particle eventually loosing its identity as a separate particle. 

 This is known in pathology as karyorrhexis and accompanies a specific 

 kind of degeneration of the tissue. The corpora adiposa was, there- 

 fore, degenerating under these unusual conditions. As further evidence 

 of the correctness of this interpretation should be mentioned the pres- 

 ence of polynucleate phagocytes which are also a usual feature of such 

 changes. 



The close genetic relationship between the kidneys and corpora 

 adiposa suggested that the kidney cells might be effected and so they 

 were studied. Figure 5 is a drawing of a cross section of a normal 

 kidney tubule. The nuclei are large and richly supplied with chro- 

 matin. There is a conspicuous frame-work of linin and many granular 

 particles. The cytoplasm is homogeneous and uniformly granular. These 

 normal cells are interesting to compare with th6 conditions in the 

 hemorrhagic kidney. 



