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On the genetic Kelation of Neurofibrillae to Chromatin.') 



By 

 Gaylord Swindle. 



With Plate 7-8. 



A problem quite famous for its difficulty is that of establishiiig- 

 with absolute certainty the more delicate changes involved in the 

 building of the neurofibrillae. In case of the connective-tissue the 

 lapse of approximately three quarters of a century has proved in- 

 sufficient for the development of a properly objective affirmation or 

 denial of the constancy of a direct participation of the "socalled 

 cells" in the formation of the collaginous and elastic fibers. The 

 proposition of genesis with reference to the neurofibrillae is decidedly 

 simpler however, since the possibility of an extracellular origin of 

 intracellular structures is here at its best an absurdit}^ 



The important problem by which we are confronted is accord- 

 ingly that of explaining the intracellular origin of the neurofibrillae. 

 But while the restriction of the process in question to that of a 

 cellular phenomenon seems to favor the general cause of simplicity, 

 it is nevertheless to be taken into consideration that the remaining 

 unknown quantity resolves itself into the relatively broad questions 



1) The present article was delivered for publication in July 1914 

 but delayed on accouut of the war. 



