g4 Gaylobd Swindle, 



Summary. 



The reasons for assuming a direct participation of tlie nuclei 

 in the building of the neurofibrillae are of quite definite nature. 

 The outgrowth of nuclear buds which consist internally of parallel 

 fibrillae of chromatin (chromofibrillae, or any term that implies 

 structure and origin) which later emancipate themselves from the 

 nucleus, leaving the latter to continue to persist as such, constitutes 

 a mechanism, a particular one onl}^, through which fibrillae chemic- 

 ally and morphologically different to the cytoplasm in which they 

 may come to lie, but corresponding in these respects more or less 

 closely to chromatin material, may originate quite directly from the 

 nucleus. Such a bundle of chromofibrillae, with its thicker or 

 thinner covering of cytoplasm, as may merge in the above manner 

 from the nucleus of a nerve cell, and constitute the forerunner of 

 a new fiber, which corresponds throughout to a normal neurite, 

 may be considered to be neurofibrillae. 



